Immunity to influenza virus infection induced by heterologous, inactivated vaccines
Identifieur interne : 002A18 ( Main/Exploration ); précédent : 002A17; suivant : 002A19Immunity to influenza virus infection induced by heterologous, inactivated vaccines
Auteurs : C. W. Potter [Royaume-Uni] ; R. Jennings [Royaume-Uni] ; K. Nicholson [Royaume-Uni]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1978-11-01.
English descriptors
- Teeft :
- Antibody, Antibody response, Antibody titres, Antigenic drift, Challenge infection, Challenge virus, Challenge virus infection, Hamster, Heterologous, Immunity, Immunization, Infection, Influenza, Influenza vaccines, Influenza virus, Influenza virus infection, Influenza virus vaccines, Inoculated, Inoculated intranasally, Kong vaccine, Schild, Significant immunity, Titre, Vaccine, Virus, Virus infection, Virus isolation, Virus vaccine, Virus vaccines, Volunteer.
Abstract
Abstract: The ability of inactivated influenza A vaccines to induce serum HI antibody and immunity to challenge infection was studied in hamsters and in volunteers. Groups of hamsters were immunized with 200 IU of influenza virus A/Scotland/74, A/Port Chalmers/73, A/England/72, or A/Hong Kong/68. The serum HI antibody response of animals to, and immunity to challenge infection was directly related to the known relationship between the vaccine and test viruses. Thus, hamsters given A/Hong Kong/68 or A/England/72 vaccine produced serum HI antibody and immunity to A/Hong Kong virus infection, and animals given A/Scotland/74, A/Port Chalmers/73, and A/England/72 produced antibody and immunity to A/Scotland infection. In a volunteer study, groups of students were immunized with 400 IU of the same vaccines as used above. The ability to infect these volunteers with WRL 105 virus given 4 weeks later was directly related to the vaccine-induced serum HI antibody to the challenge virus. The highest titers of serum HI antibody to A/Scotland virus were found in volunteers inoculated with homologous vaccine, lower titers were found in volunteers given A/Port Chalmers or A/England/ 72 vaccine and the lowest levels were seen in volunteers given A/Hong Kong/68 vaccine: the largest number of infections by the challenge virus was seen in volunteers given A/Hong Kong/68 vaccine, less were observed in volunteers given A/England/72 vaccine, and least were found in groups given A/Port Chalmers or A/Scotland/74 vaccine. Compared with the incidence of infection in volunteers given B/Hong Kong/73 vaccine, all groups given heterologous influenza A vaccines showed some immunity to challenge infection.
Url:
DOI: 10.1007/BF02121139
Affiliations:
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W." last="Potter">C. W. Potter</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Virology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Virology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Nicholson, K" sort="Nicholson, K" uniqKey="Nicholson K" first="K." last="Nicholson">K. Nicholson</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Communicable Diseases, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1978-11-01">1978-11-01</date><biblScope unit="volume">166</biblScope><biblScope unit="issue">1-4</biblScope><biblScope unit="page" from="99">99</biblScope><biblScope unit="page" to="108">108</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term><term>Antibody response</term><term>Antibody titres</term><term>Antigenic drift</term><term>Challenge infection</term><term>Challenge virus</term><term>Challenge virus infection</term><term>Hamster</term><term>Heterologous</term><term>Immunity</term><term>Immunization</term><term>Infection</term><term>Influenza</term><term>Influenza vaccines</term><term>Influenza virus</term><term>Influenza virus infection</term><term>Influenza virus vaccines</term><term>Inoculated</term><term>Inoculated intranasally</term><term>Kong vaccine</term><term>Schild</term><term>Significant immunity</term><term>Titre</term><term>Vaccine</term><term>Virus</term><term>Virus infection</term><term>Virus isolation</term><term>Virus vaccine</term><term>Virus vaccines</term><term>Volunteer</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The ability of inactivated influenza A vaccines to induce serum HI antibody and immunity to challenge infection was studied in hamsters and in volunteers. Groups of hamsters were immunized with 200 IU of influenza virus A/Scotland/74, A/Port Chalmers/73, A/England/72, or A/Hong Kong/68. The serum HI antibody response of animals to, and immunity to challenge infection was directly related to the known relationship between the vaccine and test viruses. Thus, hamsters given A/Hong Kong/68 or A/England/72 vaccine produced serum HI antibody and immunity to A/Hong Kong virus infection, and animals given A/Scotland/74, A/Port Chalmers/73, and A/England/72 produced antibody and immunity to A/Scotland infection. In a volunteer study, groups of students were immunized with 400 IU of the same vaccines as used above. The ability to infect these volunteers with WRL 105 virus given 4 weeks later was directly related to the vaccine-induced serum HI antibody to the challenge virus. The highest titers of serum HI antibody to A/Scotland virus were found in volunteers inoculated with homologous vaccine, lower titers were found in volunteers given A/Port Chalmers or A/England/ 72 vaccine and the lowest levels were seen in volunteers given A/Hong Kong/68 vaccine: the largest number of infections by the challenge virus was seen in volunteers given A/Hong Kong/68 vaccine, less were observed in volunteers given A/England/72 vaccine, and least were found in groups given A/Port Chalmers or A/Scotland/74 vaccine. Compared with the incidence of infection in volunteers given B/Hong Kong/73 vaccine, all groups given heterologous influenza A vaccines showed some immunity to challenge infection.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></region><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><name sortKey="Nicholson, K" sort="Nicholson, K" uniqKey="Nicholson K" first="K." last="Nicholson">K. Nicholson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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